{"id":45241,"date":"2023-05-17T16:20:00","date_gmt":"2023-05-17T08:20:00","guid":{"rendered":"https:\/\/www.gene-optimal.com\/?p=45241"},"modified":"2023-08-04T10:09:52","modified_gmt":"2023-08-04T02:09:52","slug":"paper01","status":"publish","type":"post","link":"https:\/\/www.gene-optimal.com\/paper01\/","title":{"rendered":"\u7ed3\u6838\u5206\u679d\u6746\u83cc\u57fa\u56e0\u6572\u9664\u4ee3\u8868\u6027\u5ba2\u6237\u6587\u7ae0"},"content":{"rendered":"<p><strong>1<\/strong><strong>\u3001Rv2346c enhances mycobacterial survival within macrophages by inhibiting TNF-\u03b1 and IL-6 production via the p38\/miRNA\/NF-\u03baB pathway<\/strong><\/p>\n<p>Rv2346c\u901a\u8fc7p38\/miRNA\/NF-\u03baB\u9014\u5f84\u6291\u5236TNF-\u03b1\u548cIL-6\u7684\u4ea7\u751f\uff0c\u589e\u5f3a\u5206\u679d\u6746\u83cc\u5728\u5de8\u566c\u7ec6\u80de\u5185\u7684\u5b58\u6d3b<\/p>\n<p>\u671f\u520a\uff1aEmerg Microbes Infect\uff0cIF=19.568 (2\u533aQ1)<\/p>\n<p>\u5355\u4f4d\uff1a\u5357\u4eac\u533b\u79d1\u5927\u5b66\u7b2c\u4e8c\u9644\u5c5e\u533b\u9662<\/p>\n<p>\u65f6\u95f4\uff1a2018\u5e749\u6708<\/p>\n<p>\u5173\u8054\u4ea7\u54c1\uff1aRv2346c\u6572\u9664\u83cc\u682a<\/p>\n<p>\u8be6\u7ec6\u8bf7\u770b\uff1a<a href=\"https:\/\/www.gene-optimal.com\/emerg-microbes-infect-rv2346c\/\">\u559c\u8baf\uff1a\u6676\u8bfa\u751f\u7269\u52a9\u529b\u79d1\u7814\u56e2\u961f\u5728Nature\u65d7\u4e0b\u671f\u520a\u53d1\u8868\u6587\u7ae0<\/a><\/p>\n<p>&nbsp;<\/p>\n<p><strong>2<\/strong><strong>\u3001Mycobacterial EST12 activates a RACK1\u2013NLRP3\u2013gasdermin D pyroptosis\u2013IL-1\u03b2 immune pathway<\/strong><\/p>\n<p>\u5206\u679d\u6746\u83ccEST12\u6fc0\u6d3bRACK1\u2013NLRP3\u2013gasdermin D pyroptosis\u2013IL-1\u03b2\u514d\u75ab\u9014\u5f84<\/p>\n<p>\u671f\u520a\uff1aScience Advances\uff0cIF=14.957 (1\u533aQ1)<\/p>\n<p>\u5355\u4f4d\uff1a\u6b66\u6c49\u5927\u5b66<\/p>\n<p>\u65f6\u95f4\uff1a2020\u5e7410\u6708<\/p>\n<p>\u5173\u8054\u4ea7\u54c1\uff1aEST12\u6572\u9664\u83cc\u682a<\/p>\n<p>\u8be6\u7ec6\u8bf7\u770b\uff1a<a href=\"https:\/\/www.gene-optimal.com\/sciad-est12\/\">\u6676\u8bfa\u52a9\u529b\u6b66\u6c49\u5927\u5b66\u79d1\u7814\u56e2\u961f\u5728science\u5b50\u520a\u53d1\u8868\u6587\u7ae0\uff01<\/a><\/p>\n<p>&nbsp;<\/p>\n<p><strong>3<\/strong><strong>\u3001Host MKRN1-Mediated Mycobacterial PPE Protein Ubiquitination Suppresses Innate Immune Response<\/strong><\/p>\n<p>\u5bbf\u4e3bMKRN1\u4ecb\u5bfc\u7684\u5206\u679d\u6746\u83ccPPE\u86cb\u767d\u6cdb\u7d20\u6291\u5236\u5148\u5929\u514d\u75ab\u53cd\u5e94<\/p>\n<p>\u671f\u520a\uff1aFrontiers in Immunology\uff0cIF=8.786 (2\u533aQ1)<\/p>\n<p>\u5355\u4f4d\uff1a\u6b66\u6c49\u5927\u5b66<\/p>\n<p>\u65f6\u95f4\uff1a2022\u5e745\u6708<\/p>\n<p>\u5173\u8054\u4ea7\u54c1\uff1aPPE68\u6572\u9664\u83cc\u682a<\/p>\n<p>&nbsp;<\/p>\n<p><strong>4\u3001<em>Mycobacterium tuberculosis<\/em> Rv0494 Protein Contributes to Mycobacterial Persistence<\/strong><\/p>\n<p>\u671f\u520a\uff1aInfection and Drug Resistance (3\u533aQ2)<\/p>\n<p>\u5355\u4f4d\uff1a\u676d\u5dde\u533b\u5b66\u9662<\/p>\n<p>\u65f6\u95f4\uff1a2023\u5e747\u6708<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>1\u3001Rv2346c enhances mycoba&#8230;<\/p>\n","protected":false},"author":1,"featured_media":45251,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[107],"tags":[],"_links":{"self":[{"href":"https:\/\/www.gene-optimal.com\/wp-json\/wp\/v2\/posts\/45241"}],"collection":[{"href":"https:\/\/www.gene-optimal.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.gene-optimal.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.gene-optimal.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.gene-optimal.com\/wp-json\/wp\/v2\/comments?post=45241"}],"version-history":[{"count":7,"href":"https:\/\/www.gene-optimal.com\/wp-json\/wp\/v2\/posts\/45241\/revisions"}],"predecessor-version":[{"id":45307,"href":"https:\/\/www.gene-optimal.com\/wp-json\/wp\/v2\/posts\/45241\/revisions\/45307"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.gene-optimal.com\/wp-json\/wp\/v2\/media\/45251"}],"wp:attachment":[{"href":"https:\/\/www.gene-optimal.com\/wp-json\/wp\/v2\/media?parent=45241"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.gene-optimal.com\/wp-json\/wp\/v2\/categories?post=45241"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.gene-optimal.com\/wp-json\/wp\/v2\/tags?post=45241"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}