{"id":41558,"date":"2019-09-24T14:31:30","date_gmt":"2019-09-24T06:31:30","guid":{"rendered":"https:\/\/www.gene-optimal.com\/?p=41558"},"modified":"2023-12-05T13:18:14","modified_gmt":"2023-12-05T05:18:14","slug":"tb_ppe38","status":"publish","type":"post","link":"https:\/\/www.gene-optimal.com\/tb_ppe38\/","title":{"rendered":"\u7ed3\u6838\u5206\u679d\u6746\u83cc\u6bd2\u529b\u57fa\u56e0\u7814\u7a76"},"content":{"rendered":"

\u5bf9\u7ed3\u6838\u5206\u679d\u6746\u83cc\u81f4\u75c5\u673a\u5236\u7684\u7814\u7a76\u4e00\u76f4\u662f\u4e16\u754c\u8303\u56f4\u5173\u6ce8\u7684\u70ed\u70b9\u3002\u7ed3\u6838\u5206\u679d\u6746\u83cc4000\u591a\u4e2a\u57fa\u56e0\u4e2d\u6709\u591a\u5c11\u57fa\u56e0\/\u86cb\u767d\u548c\u81f4\u75c5\u76f8\u5173\uff1f\u54ea\u4e9b\u86cb\u767d\u8d28\u662f\u5173\u952e\u7684\u81f4\u75c5\u56e0\u5b50\uff1f\u5173\u952e\u81f4\u75c5\u56e0\u5b50\u53c8\u662f\u5982\u4f55\u53d1\u6325\u4f5c\u7528\uff1f\u7814\u7a76\u6bd2\u529b\u57fa\u56e0\u5bf9\u4e86\u89e3\u7ed3\u6838\u5206\u679d\u6746\u83cc\u81f4\u75c5\u673a\u5236\u3001\u75c5\u83cc\u4e0e\u5bbf\u4e3b\u4e4b\u95f4\u7684\u76f8\u4e92\u5173\u7cfb\u7b49\u81f3\u5173\u91cd\u8981\uff0c\u5bf9\u66f4\u597d\u8bca\u65ad\u7ed3\u6838\u3001\u7814\u53d1\u65b0\u836f\u3001\u65b0\u75ab\u82d7\u90fd\u6709\u63a8\u52a8\u4f5c\u7528\u3002<\/p>\n

\u4eca\u5929\u5c0f\u7f16\u5c31\u548c\u5404\u4f4d\u8001\u5e08\u4e00\u8d77\u5b66\u4e60\u51e0\u7bc7\u91cd\u8981\u6bd2\u529b\u57fa\u56e0\u7814\u7a76\u7684\u6587\u7ae0\uff0c\u603b\u7ed3\u4e00\u4e0b\u5178\u578b\u6bd2\u529b\u57fa\u56e0\u7814\u7a76\u7684<\/strong>\u5957\u8def<\/strong>\u3002<\/strong><\/p>\n

\u6587\u732e1\uff1a<\/strong>ppe38<\/em>\u57fa\u56e0\u7f3a\u5931\u5bfc\u81f4\u7ed3\u6838\u5206\u679d\u6746\u83cc\u6bd2\u529b\u589e\u5f3a<\/strong><\/span><\/p>\n

\u4e00\u3001\u7814\u7a76\u601d\u8def<\/strong><\/p>\n

1.<\/strong>\u76ee\u7684\u57fa\u56e0\u9009\u62e9\uff1a<\/strong>\u5317\u4eac\u578b\u83cc\u682aSAWC_2135\u4e0eSAWC_2088\u76f8\u6bd4ppe38<\/em>\u7f3a\u5931\uff0c\u6bd2\u529b\u660e\u663e\u589e\u5f3a\uff0c\u6bd2\u529b\u589e\u5f3a\u662f\u5426\u7531ppe38<\/em>\u7f3a\u5931\u6240\u5f15\u8d77\uff1f<\/p>\n

2.<\/strong>\u7a81\u53d8\u83cc\u682a\u7684\u6784\u5efa\uff1a<\/strong>\u6784\u5efaSAWC_2135 pMV-ppe38-71<\/em>\u56de\u8865\u83cc\u682a\uff0c\u6bd4\u8f83\u5206\u6790SAWC_2088\u3001SAWC_2135\u4e0eSAWC_2135::pMV-ppe38-71<\/em>\u56de\u8865\u91cd\u7ec4\u83cc\u682a\u7684\u6bd2\u6027\uff1b\u4e3a\u8fdb\u4e00\u6b65\u9a8c\u8bc1\uff0c\u4ee5CDC1551\u4e3a\u51fa\u53d1\u83cc\u682a\uff0c\u6784\u5efappe38\u4f4d\u70b9\u7f3a\u5931\u7a81\u53d8\u83cc\u682a\u2206ppe38-71<\/em>\u53ca\u56de\u8865\u83cc\u682a\u2206ppe38-71<\/em>-C\uff0c\u6bd4\u8f83\u5206\u6790\u6bd2\u6027\u5dee\u5f02\u3002<\/p>\n

3.<\/strong>\u7ed3\u6838\u5206\u679d\u6746\u83cc\u7a81\u53d8\u83cc\u682a\u4f53\u5185\u6bd2\u6027\u5206\u6790\uff1a<\/strong>\u5c0f\u9f20\u5b9e\u9a8c\uff0c\u6d4b\u5b9a\u80ba\u90e8\u83cc\u8f7d\u91cf\u3001\u80ba\u90e8\u708e\u75c7\u548c\u5c0f\u9f20\u5b58\u6d3b\u7387\u3002<\/p>\n

\u6ce8\uff1appe38<\/em>\u4e0a\u6e38\u57fa\u56e0\u5305\u542besxG<\/em>\u3001esxH<\/em>\u3001ppe71<\/em>\u3002CDC1551\u4e3a\u7ed3\u6838\u5206\u679d\u6746\u83cc\u4e34\u5e8a\u5206\u79bb\u83cc\u682a\uff0cSAWC_2088\u3001SAWC_2135\u3001SAWC_2701\u4e3a\u5317\u4eac\u578b\u7ed3\u6838\u5206\u679d\u6746\u83cc\u4e34\u5e8a\u5206\u79bb\u83cc\u682a\uff0c\u5176\u4e2dSAWC_2088\u4e3a\u4e2d\u7b49\u6bd2\u6027\u83cc\u682a\uff0cppe38\u4f4d\u70b9\u4e2d\u63d2\u5165\u4e86IS6110\u4f4d\u70b9\uff1bSAWC_2135\u4e3a\u9ad8\u6bd2\u6027\u83cc\u682a\uff0cppe38\u4f4d\u70b9\u7f3a\u5931\u7a81\u53d8\u83cc\u682a\uff0c\u5176\u4e2desxX<\/em>\u3001esxY<\/em>\u4e24\u4e2a\u57fa\u56e0\u7f3a\u5931\uff0cppe38<\/em>\u3001ppe71<\/em>\u4e24\u4e2a\u57fa\u56e0\u90e8\u5206\u7f3a\u5931\u3002\u2206ppe38-71\u7a81\u53d8\u83cc\u682a\u662f\u5c06\u57fa\u56e0ppe38<\/em>\u3001esxX<\/em>\u3001esxY<\/em>\u3001ppe71<\/em>\u5168\u90e8\u6572\u9664\u6240\u5f97\u5230\u7684\u57fa\u56e0\u6572\u9664\u83cc\u682a\u3002<\/span><\/p>\n

\u4e8c\u3001\u4e3b\u8981\u5b9e\u9a8c\u5185\u5bb9\u548c\u7ed3\u679c<\/strong><\/p>\n

\"\"<\/p>\n

a: SAWC_2088\u3001SAWC_2135\u3001SAWC_2135-C\u611f\u67d3\u5c0f\u9f20\u5b58\u6d3b\u7387<\/span><\/p>\n

b: SAWC_2088\u3001SAWC_2135\u3001SAWC_2135-C\u611f\u67d3\u5c0f\u9f20\u7ec6\u83cc\u80ba\u8d1f\u62c5<\/span><\/p>\n

c: CDC1551\u3001\u2206ppe38-71<\/em>\u3001\u2206ppe38-71<\/em>-C\u611f\u67d3\u5c0f\u9f20\u5b58\u6d3b\u7387<\/span><\/p>\n

d: CDC1551\u3001\u2206ppe38-71<\/em>\u3001\u2206ppe38-71<\/em>-C\u611f\u67d3\u5c0f\u9f20\u7ec6\u83cc\u80ba\u8d1f\u62c5<\/span><\/p>\n

\u5206\u522b\u7528\u83cc\u682aSAWC_2088\u3001SAWC_2135\u53ca SAWC_2135::pMV-ppe38-71<\/em>\u56de\u8865\u91cd\u7ec4\u83cc\u682a\u611f\u67d3\u5c0f\u9f20\uff0c\u7ed3\u679c\u89c1\u56fea\u3001b\u3002SAWC_2088\u83cc\u682a\u5728\u611f\u67d3\u7684\u524d14\u5929\u80ba\u90e8\u7ec6\u83cc\u8f7d\u91cf\u968f\u611f\u67d3\u65f6\u95f4\u589e\u52a0\u800c\u589e\u52a0\uff0c\u4e4b\u540e\u80ba\u90e8\u7ec6\u83cc\u8f7d\u91cf\u8d8b\u4e8e\u7a33\u5b9a\u6216\u6709\u6240\u51cf\u5c11\u3002\u8fd9\u79cd\u8f83\u4f4e\u7684\u80ba\u90e8\u83cc\u8f7d\u91cf\u5bf9\u5e94\u8f83\u4f4e\u7684\u6b7b\u4ea1\u7387\uff0c\u5728\u611f\u67d3130\u5929\u540e\uff0c78%\u5c0f\u9f20\u5b58\u6d3b\u3002\u9ad8\u6bd2\u529b\u83cc\u682aSAWC_2135\u611f\u67d3\u5c0f\u9f2014\u5929\u540e\uff0c\u80ba\u90e8\u7ec6\u83cc\u8f7d\u91cf\u660e\u663e\u9ad8\u4e8eSAWC_2088\uff0c\u4e14\u968f\u611f\u67d3\u65f6\u95f4\u8fdb\u4e00\u6b65\u589e\u9ad8\uff0c\u611f\u67d328\u5929\u540e\u8fbe\u5230\u6700\u9ad8\u503c\u3002\u76f8\u5e94\u5730\u81f4\u6b7b\u7387\u4e5f\u660e\u663e\u9ad8\u4e8eSAWC_2088\u3002\u5c06ppe38-71<\/em>\u56de\u8865\u8fdbSAWC_2135\u540e\uff0c\u56de\u8865\u682a\u548cSAWC_2135\u76f8\u6bd4\uff0c\u83cc\u8f7d\u91cf\u548c\u81f4\u6b7b\u7387\u90fd\u5927\u5e45\u5ea6\u964d\u4f4e\u3002\u7ed3\u679c\u8868\u660eppe38\u4f4d\u70b9\u7684\u7f3a\u5931\u589e\u8fdbSAWC_2135\u83cc\u682a\u5728\u4f53\u5185\u7684\u751f\u957f\u80fd\u529b\uff0c\u81f4\u75c5\u6027\u66f4\u5f3a\u3002<\/p>\n

\u4e3a\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4ee5\u4e0a\u7ed3\u8bba\uff0c\u4ee5\u4e2d\u6bd2\u6027\u83cc\u682aCDC1551\u4e3a\u51fa\u53d1\u83cc\u682a\uff0c\u6784\u5efappe38\u4f4d\u70b9\u7f3a\u5931\u7a81\u53d8\u83cc\u682a\u2206ppe38-71<\/em>\u53ca\u56de\u8865\u83cc\u682a\u2206ppe38-71<\/em>-C\uff0c\u5206\u522b\u611f\u67d3\u5c0f\u9f20\uff0c\u7ed3\u679c\u89c1\u56fec\u3001d\u3002\u611f\u67d3\u540e60\u5929\u65f6\uff0c\u4f4d\u70b9\u7f3a\u5931\u7a81\u53d8\u83cc\u682a\u7684\u7ec6\u83cc\u8f7d\u91cf\u6bd4\u91ce\u751f\u578b\u548c\u56de\u8865\u682a\u9ad810\u500d\u4ee5\u4e0a\uff0c\u76f8\u5e94\u5730\u80ba\u90e8\u708e\u75c7\u66f4\u4e3a\u4e25\u91cd\uff08\u5982\u4e0b\u56fe\u6240\u793a\uff09\u300263%\u611f\u67d3\u91ce\u751f\u578bCDC1551\u7684\u5c0f\u9f20\u53ef\u4ee5\u5b58\u6d3b\u5230\u611f\u67d3\u540e130\u5929\uff0c\u800c\u6240\u6709\u611f\u67d3\u0394ppe38-71<\/em>\u7684\u5c0f\u9f20\u5728\u611f\u67d3121\u5929\u65f6\u5168\u90e8\u6b7b\u4ea1\uff0c\u56de\u8865\u682a\u5728\u611f\u67d3130\u5929\u65f6\u5b58\u6d3b\u7387\u53ef\u8fbe95%\u3002\u4ece\u800c\u53ef\u4ee5\u5f97\u51fa\u7ed3\u8bba\uff1appe38<\/strong><\/em>\u7f3a\u5931\u5bf9\u5206\u679d\u6746\u83cc\u7684\u6bd2\u529b\u6709\u663e\u8457\u5f71\u54cd\uff0c\u589e\u52a0\u4e86\u83cc\u4f53\u7684\u4f53\u5185\u751f\u957f\u901f\u5ea6\u548c\u5b58\u6d3b\u80fd\u529b\uff0c\u589e\u5f3a\u80ba\u90e8\u708e\u75c7\uff0c\u4f7f\u83cc\u4f53\u5177\u6709\u66f4\u9ad8\u7684\u81f4\u75c5\u6027\u548c\u81f4\u6b7b\u7387\u3002<\/strong><\/p>\n

\"\"<\/strong><\/p>\n

\u80ba\u90e8\u708e\u75c7\u5206\u6790<\/p>\n

\u6587\u732e2\uff1aESX-3 \u7cfb\u7edf\u5404\u7ec4\u6210\u57fa\u56e0\u4e0e\u7ed3\u6838\u5206\u679d\u6746\u83cc\u6bd2\u529b<\/strong><\/span><\/p>\n

\u4e00\u3001\u7814\u7a76\u601d\u8def<\/strong><\/p>\n

1.\u00a0<\/strong>\u76ee\u7684\u57fa\u56e0\u9009\u62e9<\/strong>\uff1aESX-3<\/strong>\u7cfb\u7edf\u5404\u7ec4\u6210\u57fa\u56e0\u3002<\/p>\n

2.\u00a0<\/strong>\u7a81\u53d8\u83cc\u682a\u7684\u6784\u5efa<\/strong>\uff1a\u57fa\u56e0\u6572\u9664\u83cc\u682a\u2206esx-3<\/em>\u3001\u2206esx-G<\/em>\u3001\u2206esx-H<\/em>\u3001\u2206pe5-ppe4<\/em>\u3001\u0394mbtB<\/em>\u7684\u6784\u5efa\uff0c\u4ee5\u53ca\u56de\u8865\u83cc\u682a\u2206esx-3<\/em>::esx-3<\/em>TB<\/sub><\/em>\u3001\u2206esxH<\/em>::esxGH<\/em>\u3001\u2206pe5-ppe4<\/em>::pe5-ppe4<\/em>\u7684\u6784\u5efa\uff0c\u8fdb\u4e00\u6b65\u63ed\u793aESX-3<\/strong>\u7cfb\u7edf\u5404\u7ec4\u6210\u57fa\u56e0\u4e0e\u7ed3\u6838\u6bd2\u529b\u7684\u76f8\u5173\u6027\u3002<\/p>\n

3.\u00a0<\/strong>\u7ed3\u6838\u5206\u679d\u6746\u83cc\u7a81\u53d8\u83cc\u682a\u4f53\u5185\u6bd2\u6027\u5206\u6790\uff1a<\/strong>\u5c0f\u9f20\u5b9e\u9a8c\uff0c\u6d4b\u5b9a\u5c0f\u9f20\u5b58\u6d3b\u7387\u53ca\u5c0f\u9f20\u5404\u5668\u5b98\u7ec6\u83cc\u8f7d\u91cf\u3002<\/p>\n

\u6ce8\uff1aESX-3\u7cfb\u7edf\u7ec4\u6210\u57fa\u56e0\u6709\uff1aRv0282-Rv0292\uff0c\u2206esx-3<\/em>\u4e3a\u5b8c\u6574\u57fa\u56e0\u7c07\u6572\u9664\u83cc\u682a\u3001\u2206esx-G<\/em>\u4e3aRv0287\u57fa\u56e0\u6572\u9664\u83cc\u682a\u3001\u2206esx-H<\/em>\u4e3aRv0288\u57fa\u56e0\u6572\u9664\u83cc\u682a\u3001\u2206pe5-ppe4<\/em>\u4e3aRv0285-Rv0286\u57fa\u56e0\u6572\u9664\u83cc\u682a\u3001\u0394mbtB<\/em>\u662fRv2383c\u57fa\u56e0\u6572\u9664\u83cc\u682a\u3002<\/span><\/p>\n

\u4e8c\u3001\u4e3b\u8981\u5b9e\u9a8c\u5185\u5bb9\u548c\u7ed3\u679c<\/strong><\/p>\n

\"\"<\/p>\n

\u5c0f\u9f20\u5206\u522b\u6ce8\u5c04\u7ed3\u6838\u5206\u679d\u6746\u83ccH37Rv\u53ca\u2206esx-3<\/em>\u7a81\u53d8\u83cc\u682a\uff0c\u5242\u91cf\u4e3a104<\/sup>cfu\u548c107<\/sup>cfu\uff0c\u7ed3\u679c\u89c1\u56feA\u3002\u6ce8\u5c04\u7ed3\u6838\u5206\u679d\u6746\u83ccH37Rv\u7684\u5c0f\u9f20\u5728\u611f\u67d340\u5929\u540e\u5168\u90e8\u6b7b\u4ea1\uff0c\u800c\u6ce8\u5c04\u4e86\u7a81\u53d8\u83cc\u682a\u2206esx-3<\/em>\u7684\u5c0f\u9f20\u5168\u90e8\u5b58\u6d3b\uff0c\u53ef\u89c1\u2206esx-3<\/em>\u7a81\u53d8\u83cc\u682a\u7684\u6bd2\u529b\u51cf\u5f31\u3002<\/p>\n

\u4e3a\u8fdb\u4e00\u6b65\u63ed\u793aESX-3<\/strong>\u7cfb\u7edf\u5404\u7ec4\u6210\u57fa\u56e0\u4e2d\u54ea\u4e9b\u662f\u5173\u952e\u7684\u6bd2\u529b\u57fa\u56e0\uff0c\u5c0f\u9f20\u5206\u522b\u6ce8\u5c04\u7ed3\u6838\u5206\u679d\u6746\u83ccH37Rv\u3001\u0394mbtB<\/em>\u3001\u2206esx-3<\/em>\u3001\u2206esx-3<\/em>::esx-3<\/em>TB<\/sub><\/em>\u3001\u2206esxH<\/em>\u3001\u2206esxH<\/em>::esxGH<\/em>\u3001\u2206pe5<\/em>–ppe4<\/em>\u3001\u2206pe5-ppe4<\/em>::pe5-ppe4<\/em>\uff0c\u7ed3\u679c\u89c1\u56feB\u3002\u611f\u67d3H37Rv\u7684\u5c0f\u9f20\u5e73\u5747\u751f\u5b58\u65f6\u95f4\u4e3a22\u5929\uff0c\u611f\u67d3\u7a81\u53d8\u83cc\u682a\u2206pe5-ppe4<\/em>\u3001\u2206mbtB<\/em>\u7684\u5c0f\u9f20\u5e73\u5747\u751f\u5b58\u65f6\u95f4\u4e3a27\u5929\uff0c\u611f\u67d3\u7a81\u53d8\u83cc\u682a\u2206esx-H<\/em>\u7684\u5c0f\u9f20\u5e73\u5747\u751f\u5b58\u65f6\u95f4\u4e3a65\u5929\u3002\u611f\u67d3\u7a81\u53d8\u83cc\u682a\u2206esx-3<\/em>\u7684\u5c0f\u9f20\u5168\u90e8\u5b58\u6d3b\uff0c\u800cesx-3<\/em>\u57fa\u56e0\u7684\u56de\u8865\u682a\u2206esx-3<\/em>::esx-3<\/em>TB<\/sub><\/em>\u5e73\u5747\u751f\u5b58\u65f6\u95f4\u4e3a19\u5929\uff0c\u8868\u73b0\u4e3a\u9ad8\u6bd2\u3002\u53ef\u89c1\uff0c\u7a81\u53d8\u83cc\u682a\u0394pe5-ppe4<\/em>\u3001\u0394mbtB<\/em>\u5728\u4f53\u5185\u53ea\u662f\u8f7b\u5fae\u7684\u51cf\u6bd2\uff0c\u800c\u7a81\u53d8\u83cc\u682a\u2206esxH<\/em>\u6bd2\u529b\u5927\u5927\u964d\u4f4e\uff0c\u8868\u660eESX-3<\/strong>\u7cfb\u7edf\u4e2desxH\u53ef\u80fd\u662f\u9ad8\u6bd2\u529b\u56e0\u5b50\u3002<\/p>\n

\"\"<\/p>\n

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    \n
  1. \u76ee\u6807\u57fa\u56e0\u9009\u62e9\uff08\u6839\u636e\u751f\u7269\u4fe1\u606f\u5b66\u5206\u6790\u57fa\u56e0\u529f\u80fd\u6216\u8005\u4e34\u5e8a\u682a\u8868\u578b\u53d8\u5316\u9009\u5b9a\u57fa\u56e0\uff09\uff1b<\/li>\n
  2. \u5bf9\u6807\u51c6\u83cc\u682a\u8fdb\u884c\u9057\u4f20\u64cd\u4f5c\uff08\u57fa\u56e0\u6572\u9664\u3001\u8fc7\u8868\u8fbe\u3001\u70b9\u7a81\u53d8\u7b49\uff09\uff0c\u83b7\u5f97\u7a81\u53d8\u83cc\u682a\uff1b<\/li>\n
  3. \u7ed3\u6838\u5206\u679d\u6746\u83cc\u7a81\u53d8\u83cc\u682a\u4f53\u5185\u5916\u6bd2\u6027\u5206\u6790\uff08\u52a8\u7269\u3001\u7ec6\u80de\u5b9e\u9a8c\u7b49\uff09\uff0c\u540c\u65f6\u4e5f\u53ef\u901a\u8fc7\u8868\u578b\u53d8\u5316\u5206\u6790\u3001\u7ec4\u5b66\u5206\u6790\u7b49\u8fdb\u4e00\u6b65\u786e\u5b9a\u57fa\u56e0\u529f\u80fd\u3002<\/li>\n<\/ol>\n

    \u5bf9\u6bd2\u529b\u57fa\u56e0\u7684\u7814\u7a76\u5957\u8def\u53ef\u6982\u62ec\u4e3a\uff1a<\/p>\n

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    \n~\u6b22\u8fce\u8ba8\u8bba\u4ea4\u6d41~<\/span><\/p>\n

    \u53c2\u8003\u6587\u732e\uff1a<\/span><\/p>\n

      \n
    1. Louis S.Ates, Anzaan Dippenaar, Roy Ummels, et al<\/em>.,\u00a0Mutations in\u00a0ppe38<\/em>\u00a0block PE_PGRS secretion and increase virulence of\u00a0Mycobacterium tuberculosis<\/em>. Nature\u00a0Microbiology, 2018 Feb;3(2):181-188.<\/span><\/li>\n
    2. Tufariello JM, Chapman JR, Kerantzas CA, et al<\/em>., Separable roles for\u00a0Mycobacterium tuberculosis<\/em>\u00a0ESX-3 effectors in iron acquisition and virulence.\u00a0Proc Natl Acad Sci U S A, 2016 Jan 19;113(3):E348-57.<\/span><\/li>\n
    3. Quanxin Long, Xiaohong Xiang, Qingqin Yin, et al<\/em>., PE_PGRS62 promotes the survival of\u00a0Mycobacterium smegmatis<\/em>\u00a0within macrophages via disrupting ER stress\u2010mediated apoptosis. J Cell Physiol, 2019 Nov;234(11):19774-19784.<\/span><\/li>\n<\/ol>\n

       <\/p>\n

      \u8054\u7cfb\u6211\u4eec<\/p>\n

      \u4e0a\u6d77\u6676\u8bfa\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8<\/p>\n

      \u7535\u8bdd\uff1a0757-29328131-616<\/p>\n

      \u624b\u673a\/\u5fae\u4fe1\uff1a13392273325<\/p>\n

      Q Q\uff1a2775427010<\/p>\n

      \u4e1a\u52a1\uff1ainfo@gene-optimal.com<\/p>\n

      \u62db\u8058\uff1ahr@gene-optimal.com<\/p>\n

      \u5730\u5740\uff1a\u5e7f\u4e1c\u7701\u4f5b\u5c71\u5e02\u4f5b\u5c71\u65b0\u57ce\u5cad\u5357\u5927\u90532\u53f7\u4e2d\u6b27\u4e2d\u5fc3A\u680b<\/p>\n

      \u5b98\u7f51\uff1awww.gene-optimal.com<\/p>\n

       <\/p>\n

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